Acrylamide and glycidamide hemoglobin adducts and epithelial ovarian cancer: a nested case-control study in non-smoking postmenopausal women from the EPIC cohort
Identifieur interne : 003214 ( Main/Exploration ); précédent : 003213; suivant : 003215Acrylamide and glycidamide hemoglobin adducts and epithelial ovarian cancer: a nested case-control study in non-smoking postmenopausal women from the EPIC cohort
Auteurs : Mireia Ob N-Santacana [Espagne] ; Leila Lujan-Barroso [Espagne] ; Ruth C. Travis [Royaume-Uni] ; Heinz Freisling [France] ; Pietro Ferrari [France] ; Gianluca Severi [Italie] ; Laura Baglietto [Australie] ; Marie-Christine Boutron-Ruault [France] ; Renée T. Fortner [Allemagne] ; Jennifer Ose [Allemagne] ; Heiner Boeing [Allemagne] ; Virginia Menéndez [Espagne] ; Emilio Sánchez-Cantalejo [Espagne] ; Saioa Chamosa [Espagne] ; José María Huerta Casta O [Espagne] ; Eva Ardanaz [Espagne] ; Kay-Tee Khaw [Royaume-Uni] ; Nick Wareham [Royaume-Uni] ; Melissa A. Merritt [Royaume-Uni] ; Marc J. Gunter [Royaume-Uni] ; Antonia Trichopoulou [Grèce] ; Eleni-Maria Papatesta [Grèce] ; Eleni Klinaki [Grèce] ; Calogero Saieva ; Giovanna Tagliabue [Italie] ; Rosario Tumino ; Carlotta Sacerdote [Italie] ; Amalia Mattiello [Italie] ; H. B. Bueno-De-Mesquita [Royaume-Uni, Pays-Bas, Malaisie] ; Petra H. Peeters [Royaume-Uni, Pays-Bas] ; N. Charlotte Onland-Moret [Pays-Bas] ; Annika Idahl [Suède] ; Eva Lundin [Suède] ; Elisabete Weiderpass [Norvège, Suède, Finlande] ; Hubert W. Vesper [États-Unis] ; Elio Riboli [Royaume-Uni] ; Eric J. Duell [Espagne]Source :
- International journal of cancer [ 0020-7136 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Acrylamide, Composés époxy, Hémoglobines.
- sang : Marqueurs biologiques.
- étiologie : Tumeurs de l'endomètre.
- Adulte d'âge moyen, Femelle, Humains, Post-ménopause, Risque, Études cas-témoins, Études prospectives.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Biomarkers.
- chemical , metabolism : Acrylamide, Epoxy Compounds, Hemoglobins.
- etiology : Endometrial Neoplasms.
- Case-Control Studies, Female, Humans, Middle Aged, Postmenopause, Prospective Studies, Risk.
Abstract
Acrylamide was classified as ‘probably carcinogenic to humans (group 2A)’ by the International Agency for Research on Cancer. Epithelial ovarian cancer (EOC) is the fourth cause of cancer mortality in women. Five epidemiological studies have evaluated the association between EOC risk and dietary acrylamide intake assessed using food frequency questionnaires, and one nested case-control study evaluated hemoglobin adducts of acrylamide (HbAA) and its metabolite glycidamide (HbGA) and EOC risk; the results of these studies were inconsistent.
A nested case-control study in non-smoking postmenopausal women (334 cases, 417 controls) was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association between HbAA, HbGA, HbAA+HbGA, and HbGA/HbAA and EOC and invasive serous EOC risk.
No overall associations were observed between biomarkers of acrylamide exposure analyzed in quintiles and EOC risk; however, positive associations were observed between some middle quintiles of HbGA and HbAA+HbGA. Elevated but non-statistically significant ORs for serous EOC were observed for HbGA and HbAA+HbGA (ORQ5
This EPIC nested case-control study failed to observe a clear association between biomarkers of acrylamide exposure and the risk of EOC or invasive serous EOC.
It is unlikely that dietary acrylamide exposure increases ovarian cancer risk; however, additional studies with larger sample size should be performed to exclude any possible association with EOC risk.
Url:
DOI: 10.1002/ijc.29853
PubMed: 26376083
PubMed Central: 4716289
Affiliations:
- Allemagne, Australie, Espagne, Finlande, France, Grèce, Italie, Malaisie, Norvège, Pays-Bas, Royaume-Uni, Suède, États-Unis
- Angleterre, Attique (région), Auvergne-Rhône-Alpes, Bade-Wurtemberg, Catalogne, Communauté de Madrid, District de Karlsruhe, Grand Londres, Oxfordshire, Piémont, Rhône-Alpes, Svealand, Utrecht (province), Victoria (État), Île-de-France, Østlandet
- Athènes, Barcelone, Heidelberg, Londres, Lyon, Madrid, Melbourne, Oslo, Oxford, Stockholm, Turin, Utrecht, Villejuif
- Université d'Oxford, Université de Melbourne
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Le document en format XML
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Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada</wicri:regionArea><wicri:noRegion>Granada</wicri:noRegion></affiliation></author><author><name sortKey="Chamosa, Saioa" sort="Chamosa, Saioa" uniqKey="Chamosa S" first="Saioa" last="Chamosa">Saioa Chamosa</name><affiliation wicri:level="1"><nlm:aff id="A15">Public Health Division of Gipuzkoa-BIODONOSTIA, Basque Regional Health Department, San Sebastian, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Public Health Division of Gipuzkoa-BIODONOSTIA, Basque Regional Health Department, San Sebastian</wicri:regionArea><wicri:noRegion>San Sebastian</wicri:noRegion></affiliation></author><author><name sortKey="Huerta Casta O, Jose Maria" sort="Huerta Casta O, Jose Maria" uniqKey="Huerta Casta O J" first="José María" last="Huerta Casta O">José María Huerta Casta O</name><affiliation wicri:level="3"><nlm:aff id="A13">CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health CIBERESP, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A16">Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia</wicri:regionArea><wicri:noRegion>Murcia</wicri:noRegion></affiliation></author><author><name sortKey="Ardanaz, Eva" sort="Ardanaz, Eva" uniqKey="Ardanaz E" first="Eva" last="Ardanaz">Eva Ardanaz</name><affiliation wicri:level="3"><nlm:aff id="A13">CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health CIBERESP, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A17">Navarra Public Health Institute, Pamplona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Navarra Public Health Institute, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A18">IdiSNA, Navarra Institute for Health Research, Pamplona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>IdiSNA, Navarra Institute for Health Research, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="1"><nlm:aff id="A19">University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge School of Clinical Medicine, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Wareham, Nick" sort="Wareham, Nick" uniqKey="Wareham N" first="Nick" last="Wareham">Nick Wareham</name><affiliation wicri:level="4"><nlm:aff id="A20">Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Merritt, Melissa A" sort="Merritt, Melissa A" uniqKey="Merritt M" first="Melissa A." last="Merritt">Melissa A. Merritt</name><affiliation wicri:level="3"><nlm:aff id="A21">Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J." last="Gunter">Marc J. Gunter</name><affiliation wicri:level="3"><nlm:aff id="A21">Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name><affiliation wicri:level="3"><nlm:aff id="A22">Hellenic Health Foundation, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A23">WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School</wicri:regionArea><wicri:noRegion>University of Athens Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Papatesta, Eleni Maria" sort="Papatesta, Eleni Maria" uniqKey="Papatesta E" first="Eleni-Maria" last="Papatesta">Eleni-Maria Papatesta</name><affiliation wicri:level="3"><nlm:aff id="A22">Hellenic Health Foundation, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Klinaki, Eleni" sort="Klinaki, Eleni" uniqKey="Klinaki E" first="Eleni" last="Klinaki">Eleni Klinaki</name><affiliation wicri:level="3"><nlm:aff id="A22">Hellenic Health Foundation, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Saieva, Calogero" sort="Saieva, Calogero" uniqKey="Saieva C" first="Calogero" last="Saieva">Calogero Saieva</name><affiliation><nlm:aff id="A24">Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence- Italy</nlm:aff><wicri:noCountry code="subfield">Florence- Italy</wicri:noCountry></affiliation></author><author><name sortKey="Tagliabue, Giovanna" sort="Tagliabue, Giovanna" uniqKey="Tagliabue G" first="Giovanna" last="Tagliabue">Giovanna Tagliabue</name><affiliation wicri:level="1"><nlm:aff id="A25">Lombardy Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Lombardy Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Tumino, Rosario" sort="Tumino, Rosario" uniqKey="Tumino R" first="Rosario" last="Tumino">Rosario Tumino</name><affiliation><nlm:aff id="A26">Cancer Registry and Histopathology Unit, “Civic - M.P.Arezzo” Hospital, ASP Ragusa (Italy)</nlm:aff><wicri:noCountry code="subfield">ASP Ragusa (Italy)</wicri:noCountry></affiliation></author><author><name sortKey="Sacerdote, Carlotta" sort="Sacerdote, Carlotta" uniqKey="Sacerdote C" first="Carlotta" last="Sacerdote">Carlotta Sacerdote</name><affiliation wicri:level="3"><nlm:aff id="A27">Unit of Cancer Epidemiology, Citta' della Salute e della Scienza Hospital-University of Turin and Center for Cancer Prevention (CPO), Torino, Italy.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Italie</country><wicri:regionArea>Unit of Cancer Epidemiology, Citta' della Salute e della Scienza Hospital-University of Turin and Center for Cancer Prevention (CPO), Torino</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Mattiello, Amalia" sort="Mattiello, Amalia" uniqKey="Mattiello A" first="Amalia" last="Mattiello">Amalia Mattiello</name><affiliation wicri:level="1"><nlm:aff id="A28">Dipartamiento di Medicina Clinica e Chirurgia Federico II University, Naples, Italy.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Italie</country><wicri:regionArea>Dipartamiento di Medicina Clinica e Chirurgia Federico II University, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Bueno De Mesquita, H B" sort="Bueno De Mesquita, H B" uniqKey="Bueno De Mesquita H" first="H. B." last="Bueno-De-Mesquita">H. B. Bueno-De-Mesquita</name><affiliation wicri:level="3"><nlm:aff id="A21">Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A29">Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A30">Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A31">Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Malaisie</country><wicri:regionArea>Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name><affiliation wicri:level="3"><nlm:aff id="A21">Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A32">Department of Epidemiology, Julius Center for Health Sciences and Primary Care,University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Julius Center for Health Sciences and Primary Care,University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N. Charlotte" last="Onland-Moret">N. Charlotte Onland-Moret</name><affiliation wicri:level="3"><nlm:aff id="A33">Julius Center for Health Scienes and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Julius Center for Health Scienes and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Idahl, Annika" sort="Idahl, Annika" uniqKey="Idahl A" first="Annika" last="Idahl">Annika Idahl</name><affiliation wicri:level="1"><nlm:aff id="A34">Department of Clinical Sciences, Obstetrics and Gynecology Nutritional Research Umeå University, Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Obstetrics and Gynecology Nutritional Research Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A35">Department of Public Health and Clinical Medicine, Nutritional Research Umeå University, Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Public Health and Clinical Medicine, Nutritional Research Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Lundin, Eva" sort="Lundin, Eva" uniqKey="Lundin E" first="Eva" last="Lundin">Eva Lundin</name><affiliation wicri:level="1"><nlm:aff id="A36">Department of Medical Biosciences, Pathology Umeå University, Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Biosciences, Pathology Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation wicri:level="1"><nlm:aff id="A37">Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Norvège</country><wicri:regionArea>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø</wicri:regionArea><wicri:noRegion>Tromsø</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A38">Department of Research, Cancer Registry of Norway, Oslo, Norway.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Norvège</country><wicri:regionArea>Department of Research, Cancer Registry of Norway, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A39">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A40">Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Vesper, Hubert W" sort="Vesper, Hubert W" uniqKey="Vesper H" first="Hubert W." last="Vesper">Hubert W. Vesper</name><affiliation wicri:level="1"><nlm:aff id="A41">Centers for Disease Control and Prevention, Atlanta, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation wicri:level="3"><nlm:aff id="A21">Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Duell, Eric J" sort="Duell, Eric J" uniqKey="Duell E" first="Eric J" last="Duell">Eric J. Duell</name><affiliation wicri:level="3"><nlm:aff id="A1">Unit of Nutrition and Cancer. Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Nutrition and Cancer. Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26376083</idno><idno type="pmc">4716289</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716289</idno><idno type="RBID">PMC:4716289</idno><idno type="doi">10.1002/ijc.29853</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001C58</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C58</idno><idno type="wicri:Area/Pmc/Curation">001B16</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001B16</idno><idno type="wicri:Area/Pmc/Checkpoint">001203</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001203</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002213</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002213</idno><idno type="wicri:Area/PubMed/Curation">002187</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002187</idno><idno type="wicri:Area/PubMed/Checkpoint">002187</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002187</idno><idno type="wicri:Area/Ncbi/Merge">002A69</idno><idno type="wicri:Area/Ncbi/Curation">002A69</idno><idno type="wicri:Area/Ncbi/Checkpoint">002A69</idno><idno type="wicri:doubleKey">0020-7136:2015:Ob N Santacana M:acrylamide:and:glycidamide</idno><idno type="wicri:Area/Main/Merge">003215</idno><idno type="wicri:Area/Main/Curation">003214</idno><idno type="wicri:Area/Main/Exploration">003214</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Acrylamide and glycidamide hemoglobin adducts and epithelial ovarian cancer: a nested case-control study in non-smoking postmenopausal women from the EPIC cohort</title><author><name sortKey="Ob N Santacana, Mireia" sort="Ob N Santacana, Mireia" uniqKey="Ob N Santacana M" first="Mireia" last="Ob N-Santacana">Mireia Ob N-Santacana</name><affiliation wicri:level="3"><nlm:aff id="A1">Unit of Nutrition and Cancer. Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Nutrition and Cancer. Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Lujan Barroso, Leila" sort="Lujan Barroso, Leila" uniqKey="Lujan Barroso L" first="Leila" last="Lujan-Barroso">Leila Lujan-Barroso</name><affiliation wicri:level="3"><nlm:aff id="A1">Unit of Nutrition and Cancer. Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Nutrition and Cancer. Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation wicri:level="3"><nlm:aff id="A2">Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, Oxford</nlm:aff><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><wicri:orgArea>Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford</wicri:orgArea></affiliation></author><author><name sortKey="Freisling, Heinz" sort="Freisling, Heinz" uniqKey="Freisling H" first="Heinz" last="Freisling">Heinz Freisling</name><affiliation wicri:level="3"><nlm:aff id="A3">Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Ferrari, Pietro" sort="Ferrari, Pietro" uniqKey="Ferrari P" first="Pietro" last="Ferrari">Pietro Ferrari</name><affiliation wicri:level="3"><nlm:aff id="A3">Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation wicri:level="3"><nlm:aff id="A4">Human Genetics Foundation (HuGeF), Torino, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Human Genetics Foundation (HuGeF), Torino</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation wicri:level="3"><nlm:aff id="A5">Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A6">Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><affiliation wicri:level="3"><nlm:aff id="A7">Inserm, CESP Centre for Research in Epidemiology and Population Health, U1018, Lifestyle, genes and health: integrative trans-generational epidemiology, F-94805, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, CESP Centre for Research in Epidemiology and Population Health, U1018, Lifestyle, genes and health: integrative trans-generational epidemiology, F-94805, Villejuif</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Villejuif</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A8">Univ Paris Sud, UMRS 1018, F-94805, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ Paris Sud, UMRS 1018, F-94805, Villejuif</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Villejuif</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A9">Gustave Roussy, F-94805, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy, F-94805, Villejuif</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Villejuif</settlement></placeName></affiliation></author><author><name sortKey="Fortner, Renee T" sort="Fortner, Renee T" uniqKey="Fortner R" first="Renée T." last="Fortner">Renée T. Fortner</name><affiliation wicri:level="3"><nlm:aff id="A10">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Ose, Jennifer" sort="Ose, Jennifer" uniqKey="Ose J" first="Jennifer" last="Ose">Jennifer Ose</name><affiliation wicri:level="3"><nlm:aff id="A10">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation wicri:level="1"><nlm:aff id="A11">Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal</wicri:regionArea><wicri:noRegion>Nuthetal</wicri:noRegion><wicri:noRegion>Nuthetal</wicri:noRegion><wicri:noRegion>Nuthetal</wicri:noRegion></affiliation></author><author><name sortKey="Menendez, Virginia" sort="Menendez, Virginia" uniqKey="Menendez V" first="Virginia" last="Menéndez">Virginia Menéndez</name><affiliation wicri:level="1"><nlm:aff id="A12">Public Health Directorate, Asturias, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Public Health Directorate, Asturias</wicri:regionArea><wicri:noRegion>Asturias</wicri:noRegion></affiliation></author><author><name sortKey="Sanchez Cantalejo, Emilio" sort="Sanchez Cantalejo, Emilio" uniqKey="Sanchez Cantalejo E" first="Emilio" last="Sánchez-Cantalejo">Emilio Sánchez-Cantalejo</name><affiliation wicri:level="3"><nlm:aff id="A13">CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health CIBERESP, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A14">Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada</wicri:regionArea><wicri:noRegion>Granada</wicri:noRegion></affiliation></author><author><name sortKey="Chamosa, Saioa" sort="Chamosa, Saioa" uniqKey="Chamosa S" first="Saioa" last="Chamosa">Saioa Chamosa</name><affiliation wicri:level="1"><nlm:aff id="A15">Public Health Division of Gipuzkoa-BIODONOSTIA, Basque Regional Health Department, San Sebastian, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Public Health Division of Gipuzkoa-BIODONOSTIA, Basque Regional Health Department, San Sebastian</wicri:regionArea><wicri:noRegion>San Sebastian</wicri:noRegion></affiliation></author><author><name sortKey="Huerta Casta O, Jose Maria" sort="Huerta Casta O, Jose Maria" uniqKey="Huerta Casta O J" first="José María" last="Huerta Casta O">José María Huerta Casta O</name><affiliation wicri:level="3"><nlm:aff id="A13">CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health CIBERESP, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A16">Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Espagne</country><wicri:regionArea>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia</wicri:regionArea><wicri:noRegion>Murcia</wicri:noRegion></affiliation></author><author><name sortKey="Ardanaz, Eva" sort="Ardanaz, Eva" uniqKey="Ardanaz E" first="Eva" last="Ardanaz">Eva Ardanaz</name><affiliation wicri:level="3"><nlm:aff id="A13">CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiology and Public Health CIBERESP, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A17">Navarra Public Health Institute, Pamplona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Navarra Public Health Institute, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A18">IdiSNA, Navarra Institute for Health Research, Pamplona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>IdiSNA, Navarra Institute for Health Research, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation wicri:level="1"><nlm:aff id="A19">University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge School of Clinical Medicine, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Wareham, Nick" sort="Wareham, Nick" uniqKey="Wareham N" first="Nick" last="Wareham">Nick Wareham</name><affiliation wicri:level="4"><nlm:aff id="A20">Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, Oxford, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Merritt, Melissa A" sort="Merritt, Melissa A" uniqKey="Merritt M" first="Melissa A." last="Merritt">Melissa A. Merritt</name><affiliation wicri:level="3"><nlm:aff id="A21">Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J." last="Gunter">Marc J. Gunter</name><affiliation wicri:level="3"><nlm:aff id="A21">Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name><affiliation wicri:level="3"><nlm:aff id="A22">Hellenic Health Foundation, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A23">WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School</wicri:regionArea><wicri:noRegion>University of Athens Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Papatesta, Eleni Maria" sort="Papatesta, Eleni Maria" uniqKey="Papatesta E" first="Eleni-Maria" last="Papatesta">Eleni-Maria Papatesta</name><affiliation wicri:level="3"><nlm:aff id="A22">Hellenic Health Foundation, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Klinaki, Eleni" sort="Klinaki, Eleni" uniqKey="Klinaki E" first="Eleni" last="Klinaki">Eleni Klinaki</name><affiliation wicri:level="3"><nlm:aff id="A22">Hellenic Health Foundation, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Saieva, Calogero" sort="Saieva, Calogero" uniqKey="Saieva C" first="Calogero" last="Saieva">Calogero Saieva</name><affiliation><nlm:aff id="A24">Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence- Italy</nlm:aff><wicri:noCountry code="subfield">Florence- Italy</wicri:noCountry></affiliation></author><author><name sortKey="Tagliabue, Giovanna" sort="Tagliabue, Giovanna" uniqKey="Tagliabue G" first="Giovanna" last="Tagliabue">Giovanna Tagliabue</name><affiliation wicri:level="1"><nlm:aff id="A25">Lombardy Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Lombardy Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Tumino, Rosario" sort="Tumino, Rosario" uniqKey="Tumino R" first="Rosario" last="Tumino">Rosario Tumino</name><affiliation><nlm:aff id="A26">Cancer Registry and Histopathology Unit, “Civic - M.P.Arezzo” Hospital, ASP Ragusa (Italy)</nlm:aff><wicri:noCountry code="subfield">ASP Ragusa (Italy)</wicri:noCountry></affiliation></author><author><name sortKey="Sacerdote, Carlotta" sort="Sacerdote, Carlotta" uniqKey="Sacerdote C" first="Carlotta" last="Sacerdote">Carlotta Sacerdote</name><affiliation wicri:level="3"><nlm:aff id="A27">Unit of Cancer Epidemiology, Citta' della Salute e della Scienza Hospital-University of Turin and Center for Cancer Prevention (CPO), Torino, Italy.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Italie</country><wicri:regionArea>Unit of Cancer Epidemiology, Citta' della Salute e della Scienza Hospital-University of Turin and Center for Cancer Prevention (CPO), Torino</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Mattiello, Amalia" sort="Mattiello, Amalia" uniqKey="Mattiello A" first="Amalia" last="Mattiello">Amalia Mattiello</name><affiliation wicri:level="1"><nlm:aff id="A28">Dipartamiento di Medicina Clinica e Chirurgia Federico II University, Naples, Italy.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Italie</country><wicri:regionArea>Dipartamiento di Medicina Clinica e Chirurgia Federico II University, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Bueno De Mesquita, H B" sort="Bueno De Mesquita, H B" uniqKey="Bueno De Mesquita H" first="H. B." last="Bueno-De-Mesquita">H. B. Bueno-De-Mesquita</name><affiliation wicri:level="3"><nlm:aff id="A21">Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A29">Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A30">Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A31">Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Malaisie</country><wicri:regionArea>Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name><affiliation wicri:level="3"><nlm:aff id="A21">Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A32">Department of Epidemiology, Julius Center for Health Sciences and Primary Care,University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Julius Center for Health Sciences and Primary Care,University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N. Charlotte" last="Onland-Moret">N. Charlotte Onland-Moret</name><affiliation wicri:level="3"><nlm:aff id="A33">Julius Center for Health Scienes and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Julius Center for Health Scienes and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Idahl, Annika" sort="Idahl, Annika" uniqKey="Idahl A" first="Annika" last="Idahl">Annika Idahl</name><affiliation wicri:level="1"><nlm:aff id="A34">Department of Clinical Sciences, Obstetrics and Gynecology Nutritional Research Umeå University, Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Obstetrics and Gynecology Nutritional Research Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A35">Department of Public Health and Clinical Medicine, Nutritional Research Umeå University, Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Public Health and Clinical Medicine, Nutritional Research Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Lundin, Eva" sort="Lundin, Eva" uniqKey="Lundin E" first="Eva" last="Lundin">Eva Lundin</name><affiliation wicri:level="1"><nlm:aff id="A36">Department of Medical Biosciences, Pathology Umeå University, Umeå, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Biosciences, Pathology Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation wicri:level="1"><nlm:aff id="A37">Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Norvège</country><wicri:regionArea>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø</wicri:regionArea><wicri:noRegion>Tromsø</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A38">Department of Research, Cancer Registry of Norway, Oslo, Norway.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Norvège</country><wicri:regionArea>Department of Research, Cancer Registry of Norway, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A39">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A40">Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Vesper, Hubert W" sort="Vesper, Hubert W" uniqKey="Vesper H" first="Hubert W." last="Vesper">Hubert W. Vesper</name><affiliation wicri:level="1"><nlm:aff id="A41">Centers for Disease Control and Prevention, Atlanta, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation wicri:level="3"><nlm:aff id="A21">Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Duell, Eric J" sort="Duell, Eric J" uniqKey="Duell E" first="Eric J" last="Duell">Eric J. Duell</name><affiliation wicri:level="3"><nlm:aff id="A1">Unit of Nutrition and Cancer. Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Nutrition and Cancer. Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author></analytic><series><title level="j">International journal of cancer</title><idno type="ISSN">0020-7136</idno><idno type="eISSN">1097-0215</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acrylamide (metabolism)</term><term>Biomarkers (blood)</term><term>Case-Control Studies</term><term>Endometrial Neoplasms (etiology)</term><term>Epoxy Compounds (metabolism)</term><term>Female</term><term>Hemoglobins (metabolism)</term><term>Humans</term><term>Middle Aged</term><term>Postmenopause</term><term>Prospective Studies</term><term>Risk</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acrylamide (métabolisme)</term><term>Adulte d'âge moyen</term><term>Composés époxy (métabolisme)</term><term>Femelle</term><term>Humains</term><term>Hémoglobines (métabolisme)</term><term>Marqueurs biologiques (sang)</term><term>Post-ménopause</term><term>Risque</term><term>Tumeurs de l'endomètre (étiologie)</term><term>Études cas-témoins</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Acrylamide</term><term>Epoxy Compounds</term><term>Hemoglobins</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Endometrial Neoplasms</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Acrylamide</term><term>Composés époxy</term><term>Hémoglobines</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Marqueurs biologiques</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Tumeurs de l'endomètre</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Postmenopause</term><term>Prospective Studies</term><term>Risk</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Post-ménopause</term><term>Risque</term><term>Études cas-témoins</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Acrylamide was classified as ‘probably carcinogenic to humans (group 2A)’ by the International Agency for Research on Cancer. Epithelial ovarian cancer (EOC) is the fourth cause of cancer mortality in women. Five epidemiological studies have evaluated the association between EOC risk and dietary acrylamide intake assessed using food frequency questionnaires, and one nested case-control study evaluated hemoglobin adducts of acrylamide (HbAA) and its metabolite glycidamide (HbGA) and EOC risk; the results of these studies were inconsistent.</p></sec><sec id="S2"><title>Methods</title><p id="P2">A nested case-control study in non-smoking postmenopausal women (334 cases, 417 controls) was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association between HbAA, HbGA, HbAA+HbGA, and HbGA/HbAA and EOC and invasive serous EOC risk.</p></sec><sec id="S3"><title>Results</title><p id="P3">No overall associations were observed between biomarkers of acrylamide exposure analyzed in quintiles and EOC risk; however, positive associations were observed between some middle quintiles of HbGA and HbAA+HbGA. Elevated but non-statistically significant ORs for serous EOC were observed for HbGA and HbAA+HbGA (OR<sub>Q5</sub><italic><sub>vs</sub></italic><sub>Q1</sub>:1.91, 95%CI:0.96-3.81 and OR<sub>Q5</sub><italic><sub>vs</sub></italic><sub>Q1</sub>:1.90, 95%CI:0.94-3.83, respectively); however, no linear dose-response trends were observed.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">This EPIC nested case-control study failed to observe a clear association between biomarkers of acrylamide exposure and the risk of EOC or invasive serous EOC.</p></sec><sec id="S5"><title>Impact</title><p id="P5">It is unlikely that dietary acrylamide exposure increases ovarian cancer risk; however, additional studies with larger sample size should be performed to exclude any possible association with EOC risk.</p></sec></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Italie</li><li>Malaisie</li><li>Norvège</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Attique (région)</li><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>Catalogne</li><li>Communauté de Madrid</li><li>District de Karlsruhe</li><li>Grand Londres</li><li>Oxfordshire</li><li>Piémont</li><li>Rhône-Alpes</li><li>Svealand</li><li>Utrecht (province)</li><li>Victoria (État)</li><li>Île-de-France</li><li>Østlandet</li></region><settlement><li>Athènes</li><li>Barcelone</li><li>Heidelberg</li><li>Londres</li><li>Lyon</li><li>Madrid</li><li>Melbourne</li><li>Oslo</li><li>Oxford</li><li>Stockholm</li><li>Turin</li><li>Utrecht</li><li>Villejuif</li></settlement><orgName><li>Université d'Oxford</li><li>Université de Melbourne</li></orgName></list><tree><noCountry><name sortKey="Saieva, Calogero" sort="Saieva, Calogero" uniqKey="Saieva C" first="Calogero" last="Saieva">Calogero Saieva</name><name sortKey="Tumino, Rosario" sort="Tumino, Rosario" uniqKey="Tumino R" first="Rosario" last="Tumino">Rosario Tumino</name></noCountry><country name="Espagne"><region name="Catalogne"><name sortKey="Ob N Santacana, Mireia" sort="Ob N Santacana, Mireia" uniqKey="Ob N Santacana M" first="Mireia" last="Ob N-Santacana">Mireia Ob N-Santacana</name></region><name sortKey="Ardanaz, Eva" sort="Ardanaz, Eva" uniqKey="Ardanaz E" first="Eva" last="Ardanaz">Eva Ardanaz</name><name sortKey="Ardanaz, Eva" sort="Ardanaz, Eva" uniqKey="Ardanaz E" first="Eva" last="Ardanaz">Eva Ardanaz</name><name sortKey="Ardanaz, Eva" sort="Ardanaz, Eva" uniqKey="Ardanaz E" first="Eva" last="Ardanaz">Eva Ardanaz</name><name sortKey="Chamosa, Saioa" sort="Chamosa, Saioa" uniqKey="Chamosa S" first="Saioa" last="Chamosa">Saioa Chamosa</name><name sortKey="Duell, Eric J" sort="Duell, Eric J" uniqKey="Duell E" first="Eric J" last="Duell">Eric J. Duell</name><name sortKey="Huerta Casta O, Jose Maria" sort="Huerta Casta O, Jose Maria" uniqKey="Huerta Casta O J" first="José María" last="Huerta Casta O">José María Huerta Casta O</name><name sortKey="Huerta Casta O, Jose Maria" sort="Huerta Casta O, Jose Maria" uniqKey="Huerta Casta O J" first="José María" last="Huerta Casta O">José María Huerta Casta O</name><name sortKey="Lujan Barroso, Leila" sort="Lujan Barroso, Leila" uniqKey="Lujan Barroso L" first="Leila" last="Lujan-Barroso">Leila Lujan-Barroso</name><name sortKey="Menendez, Virginia" sort="Menendez, Virginia" uniqKey="Menendez V" first="Virginia" last="Menéndez">Virginia Menéndez</name><name sortKey="Sanchez Cantalejo, Emilio" sort="Sanchez Cantalejo, Emilio" uniqKey="Sanchez Cantalejo E" first="Emilio" last="Sánchez-Cantalejo">Emilio Sánchez-Cantalejo</name><name sortKey="Sanchez Cantalejo, Emilio" sort="Sanchez Cantalejo, Emilio" uniqKey="Sanchez Cantalejo E" first="Emilio" last="Sánchez-Cantalejo">Emilio Sánchez-Cantalejo</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. 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Peeters</name><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><name sortKey="Wareham, Nick" sort="Wareham, Nick" uniqKey="Wareham N" first="Nick" last="Wareham">Nick Wareham</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Freisling, Heinz" sort="Freisling, Heinz" uniqKey="Freisling H" first="Heinz" last="Freisling">Heinz Freisling</name></region><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><name sortKey="Ferrari, Pietro" sort="Ferrari, Pietro" uniqKey="Ferrari P" first="Pietro" last="Ferrari">Pietro Ferrari</name></country><country name="Italie"><region name="Piémont"><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name></region><name sortKey="Mattiello, Amalia" sort="Mattiello, Amalia" uniqKey="Mattiello A" first="Amalia" last="Mattiello">Amalia Mattiello</name><name sortKey="Sacerdote, Carlotta" sort="Sacerdote, Carlotta" uniqKey="Sacerdote C" first="Carlotta" last="Sacerdote">Carlotta Sacerdote</name><name sortKey="Tagliabue, Giovanna" sort="Tagliabue, Giovanna" uniqKey="Tagliabue G" first="Giovanna" last="Tagliabue">Giovanna Tagliabue</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name></region><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Fortner, Renee T" sort="Fortner, Renee T" uniqKey="Fortner R" first="Renée T." last="Fortner">Renée T. Fortner</name></region><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><name sortKey="Ose, Jennifer" sort="Ose, Jennifer" uniqKey="Ose J" first="Jennifer" last="Ose">Jennifer Ose</name></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name></region><name sortKey="Klinaki, Eleni" sort="Klinaki, Eleni" uniqKey="Klinaki E" first="Eleni" last="Klinaki">Eleni Klinaki</name><name sortKey="Papatesta, Eleni Maria" sort="Papatesta, Eleni Maria" uniqKey="Papatesta E" first="Eleni-Maria" last="Papatesta">Eleni-Maria Papatesta</name><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name></country><country name="Pays-Bas"><noRegion><name sortKey="Bueno De Mesquita, H B" sort="Bueno De Mesquita, H B" uniqKey="Bueno De Mesquita H" first="H. B." last="Bueno-De-Mesquita">H. B. Bueno-De-Mesquita</name></noRegion><name sortKey="Bueno De Mesquita, H B" sort="Bueno De Mesquita, H B" uniqKey="Bueno De Mesquita H" first="H. B." last="Bueno-De-Mesquita">H. B. Bueno-De-Mesquita</name><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N. Charlotte" last="Onland-Moret">N. Charlotte Onland-Moret</name><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name></country><country name="Malaisie"><noRegion><name sortKey="Bueno De Mesquita, H B" sort="Bueno De Mesquita, H B" uniqKey="Bueno De Mesquita H" first="H. B." last="Bueno-De-Mesquita">H. B. Bueno-De-Mesquita</name></noRegion></country><country name="Suède"><noRegion><name sortKey="Idahl, Annika" sort="Idahl, Annika" uniqKey="Idahl A" first="Annika" last="Idahl">Annika Idahl</name></noRegion><name sortKey="Idahl, Annika" sort="Idahl, Annika" uniqKey="Idahl A" first="Annika" last="Idahl">Annika Idahl</name><name sortKey="Lundin, Eva" sort="Lundin, Eva" uniqKey="Lundin E" first="Eva" last="Lundin">Eva Lundin</name><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name></country><country name="Norvège"><noRegion><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name></noRegion><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name></country><country name="Finlande"><noRegion><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Vesper, Hubert W" sort="Vesper, Hubert W" uniqKey="Vesper H" first="Hubert W." last="Vesper">Hubert W. 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